Zone width in isopropanol (24.49 to 47.41 ☌) and the narrowest < toluene < acetonitrile with the widest solution metastable With the overall order being isopropanol < ethanol < methanol TheĬrystallizability is found to be highly dependent on the solvent type Interactions, and a concomitantly higher than ideal solubility. Is found to be the highest, consistent with the strongest solvent–solute Is examined using an integrated workflow encompassing both experimental The influence of the solution environment on the solutionĬrystallizability, and nucleation of tolfenamic acid (TFA) in fiveĭifferent solvents (isopropanol, ethanol, methanol, toluene, and acetonitrile)